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SURMOUNT-1 and TRIUMPH-4 enrolled different populations (TRIUMPH-4 included only people with knee osteoarthritis), and direct head-to-head trials comparing retatrutide and tirzepatide havent been completed
![semaglutide amino acid sequence Structure of semaglutide. The analog of human glucagon-like peptide-1 Semaglutide [LTP-V028] : LifeTein, The](https://www.lifetein.com/peptide-product/images/Semaglutide%20(1).png)
Type 2 diabetes and obesity are increasing throughout the world
Some commercial plans cover Wegovy but not Zepbound (because Wegovy was first to market and they negotiated rebates)
![semaglutide amino acid sequence Structure of semaglutide. The analog of human glucagon-like peptide-1 Semaglutide [LTP-V028] : LifeTein, The](https://www.researchgate.net/publication/383181241/figure/fig1/AS:11431281292379947@1732554048803/Amino-acid-sequences-of-GLP-1-GIP-semaglutide-and-a-balanced-dual-agonist-DA-of-both.png)
Every time you draw from your reconstituted vial, quick visual inspection tells you whether the solution likely remains active
![semaglutide amino acid sequence Structure of semaglutide. The analog of human glucagon-like peptide-1 Semaglutide [LTP-V028] : LifeTein, The](https://www.researchgate.net/publication/343265981/figure/fig1/AS:923164464910337@1597110968410/Structure-of-semaglutide-subcutaneous-formulation_Q320.jpg)
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